A Guth Labs publication

Daily digest

Tuesday, September 22, 2026

21 items

Better prompt caching for GPT-6

Learn how GPT-6 improves prompt caching with higher cache hit rates, new diagnostics, explicit breakpoints, and controls that reduce latency and costs.

  • Product
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Poitras Center to fuel early careers of 50 young scientists dedicated to psychiatric disorders research

Patricia and James Poitras ’63 provide fellowships for graduate students and postdocs who will shape the future of mental health research.

  • Giving
  • Awards, honors and fellowships
  • Students
  • Graduate, postdoctoral
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Introducing GPT-6 Sol and Luna

Meet GPT-6 Sol and Luna, two models that bring frontier intelligence to everyday work with different balances of capability and cost.

  • Product
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Claude Opus 5.5 is now available on AWS

Claude Opus 5.5, Anthropic's most capable Opus model for agentic coding, knowledge work, and long-running tasks, is now available on Amazon Bedrock and Claude Platform on AWS. This post covers what's new in Opus 5.5, practical guidance, and how to…

  • Amazon Bedrock
  • Announcements
  • Intermediate (200)
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Enabling Private High-Performance Production AI Inference with NVIDIA Confidential Computing

As large language model (LLM) inference increasingly processes sensitive information and proprietary model context across personal, enterprise, and regulated...

  • Agentic AI / Generative AI
  • Data Center / Cloud
  • Trustworthy AI / Cybersecurity
  • AI Inference
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Evaluate skill-equipped agents with Strands Evals and Amazon Bedrock AgentCore

Skills let you encode domain-specific procedures as reusable, portable instructions for agents, but a fluent answer doesn't prove the agent picked the right skill or followed it. Learn how to measure skill selection and instruction following with Strands Evals and…

  • Advanced (300)
  • Amazon Bedrock AgentCore
  • Announcements
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Topology-Aware Workload Scheduling with NVIDIA Topograph

AI factories are power-limited systems that deliver maximum value when fully optimized. GPU workload placement is a key optimization. Poor workload placement...

  • Data Center / Cloud
  • Developer Tools & Techniques
  • Networking / Communications
  • AI Factory
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How Reactiv automates mobile commerce 80% faster with Amazon Bedrock AgentCore

Reactiv used Amazon Bedrock AgentCore to build a multi-agent AI Scheduler that autonomously refreshes Shopify merchants' mobile apps on a schedule, reducing merchant configuration time by 80% and getting to production 33% faster.

  • Amazon Bedrock AgentCore
  • Customer Solutions
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Right-size generative AI endpoints with concurrency sweeps on Amazon SageMaker AI

Concurrency sweeps help you right-size a generative AI endpoint on Amazon SageMaker AI by systematically benchmarking it at increasing load levels. This post walks through deploying a model, running automated concurrency sweeps with the CreateAIBenchmarkJob API, and using the results…

  • Advanced (300)
  • Amazon SageMaker AI
  • Technical How-to
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How Trane gets building insights 60x faster with Amazon Bedrock AgentCore

In about four weeks, Trane Technologies built an AI-powered agentic solution on Amazon Bedrock AgentCore that reduced a 20-minute, multi-screen building diagnostic workflow to a 20-second natural language interaction, a 60x improvement in time-to-insight. This post shares the architectural approach…

  • Amazon Bedrock AgentCore
  • Customer Solutions
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How Tata Elxsi detects industrial safety risks in seconds on AWS

Learn how Tata Elxsi built IRIS, a real-time industrial safety platform on AWS. IRIS filters camera video at the edge, streams metadata through Amazon Kinesis, runs computer vision on Amazon SageMaker AI, and correlates detections into high-confidence alerts, detecting unsafe…

  • Amazon SageMaker AI
  • Customer Solutions
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Extending public sector intelligence with Agentforce and AWS

Public sector agencies process large volumes of unstructured evidence, such as body camera footage and scanned documents. This post shows how to combine Amazon Bedrock Data Automation with the Model Context Protocol (MCP) to turn that data into structured insights…

  • Advanced (300)
  • Amazon Bedrock AgentCore
  • Amazon Bedrock Data Automation
  • Customer Solutions
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NVIDIA Isaac ROS 5.0 Advances Agentic, Open Source Robotics Development

To build and deploy sophisticated robotics applications that can perceive, reason and act in dynamic environments, developers need new physical AI models and tools. The ROS open framework is a project from Open Robotics that helps humans build robots. NVIDIA…

  • Robotics
  • Agentic AI
  • Artificial Intelligence
  • Computer Vision
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Accelerating a ROS 2 Node with an AI Agent and NVIDIA Isaac ROS

GPU acceleration can speed up compute-intensive robotics workloads, but a fast CUDA kernel alone does not guarantee a fast ROS 2 graph. As messages move between...

  • Agentic AI / Generative AI
  • Edge Computing
  • Robotics
  • AI Agent
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